Sartorius Stedim Biotech (SSB) has launched the SARTOFLOW Smart benchtop crossflow system for optimised ultra- and diafiltration applications.
Suitable for many downstream processes, such as purification of vaccines, monoclonal antibodies and recombinant proteins, SARTOFLOW is also appropriate for flexible use in laboratory environments for process development and clinical trials as well as for cGMP environments.
The system is equipped with a low shear four-piston membrane pump that enables highest product yields to be achieved.
In addition, the pump provides a wide range of flow rates allowing choice of membrane surface areas from 50 cm² to as much as 0.14 m².
Further features include SSB’s intuitive and easy to use DCU-4 control unit which, when combined with the company’s BioPAT SCADA, MFCS-4 software, provides data logging and export.
Its touchscreen provides instant access to all critical process parameters and displays control and alarm functions. A logbook function stores alarms, set points and user logs.
The SARTOFLOW family of crossflow systems feature a 7-inch touchscreen that supports the operator with interactive prompts for easy guidance through entire process sequences.
Users can select predefined parameters to automatically run sequences for concentration, diafiltration, rinsing, filling, draining, flushing steps and tare functions.
An optional peristaltic diafiltration pump is available to load product or buffer as a discrete process step.
It is also possible to customise the system according to specific requirements.
For example, a conductivity, pH or temperature probe can be installed in the recirculation vessel.
The system can also be upgraded in the case of changing process requirements.
“SARTOFLOW Smart is a milestone development in the landscape of small crossflow systems. It combines outstanding technology with options that are normally only available with process systems. With an exceptionally wide working range of membrane surface areas, the system is the perfect tool for both R&D optimisation trials and cGMP production,” said Marc Jenke, expert for benchtop crossflow filtration systems at Sartorius Stedim Biotech.