The Razor high-throughput peptide cleavage system from CEM
27 Jun 2017
Razor, is a simple, elegant high-throughput, peptide cleavage system from CEM that produces higher purity peptides while protecting synthesis instrumentation from harsh cleavage reagents.
CEM, a leader in peptide synthesis, have produced Razor, a simple, high-throughput, peptide cleavage system that allows chemists to produce higher purity peptides, while protecting synthesis instrumentation from harsh cleavage reagents.
This unique system utilises elevated temperature for the peptide resin cleavage process to reduce reaction times at least 4 fold and promote more complete removal of side chain protecting groups, (ideal for long peptides).
The Razor cleaves up to 12 peptides in parallel in only 30 minutes making it ideal for both standard and high throughput workflows. The system features a pre-cleavage washing station, a 12-position heating block with temperature control, and a collection tray with efficient, independent vacuum draining. And, advantageously, the Razor’s compact design allows it to be easily sited in standard fume hoods, while the detached module protects peptide synthesisers from the corrosive effects of trifluoroacetic acid (TFA).
With the Razor chemists can now cleave peptides as quickly as they purify them. With microcleavage in as little as 2 minutes the Razor provides mass spectrometry level confidence that expensive amino acids and scale-up syntheses are coupled completely. Plus full cleavage in 30 minutes or less, will accelerate the purification workflow of laboratories permitting access to purified peptides faster than any other method.
The Razor also allows laboratories to stay running around the clock, despite the harsh cleavage reagents and scavengers in use. The elegant design of the Razor incorporates disposable vessels and there are no complicated valve block systems, which can require expensive, technician-only maintenance.
Combining straightforward clean up procedures and simple design, the Razor from CEM ensures integrity of peptide purity with maximum user convenience.