Malvern Instruments has posted an application note demonstrating its Viscotek SEC-MALS 20 multi angle light scattering (MALS) detector for size exclusion chromatography.
The application note ‘Molecular weight measurements of an antibody using Viscotek SEC-MALS 20’ reported experimental data for the analysis of aggregates within monoclonal antibody formulations and is free to download.
Monoclonal antibodies are being targeted for use in a growing range of therapeutic applications.
Measuring the molecular weight of the protein, monomer, oligomers and aggregates within the sample and in formulations is an important part of assessing their safety and efficacy as drugs.
Light scattering techniques allow the measurement of absolute molecular weight without relying on potentially inaccurate calibration methods, with MALS an established technology within the industry.
When added to a GPC/SEC chromatography system, the Viscotek SEC-MALS 20 delivers MALS detector performance with high accuracy, even at high molecular weights.
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