A technical article from Genevac details how its HT-24 centrifugal system can find and isolate novel flavour ingredients from nature.
Natural product derived discovery of novel flavour molecules is a highly complex process. Natural product sources yield complex extracts containing many components, which often do not lend themselves to processing and analysis.
Conventionally, many steps of fractionation and evaluation are necessary until a compound is obtained from natural sources at the purity required for structural analysis.
In the article a state of the art fractionation process using a Sepbox Preparative HPLC - SPE system* and a Genevac HT-24 centrifugal evaporator is described.
The Sepbox enables two dimensional, preparative scale fractionation of natural products using high performance liquid chromatography – solid phase extraction (HPLC-SPE).
In sequential HPLC-SPE / HPLC-SPE steps individual components are isolated from complex mixtures. Each separation run produced 320 samples of approximately 45ml volume.
A Genevac HT-24 Evaporator was chosen to dry the samples because of its high sample capacity, unique technology that eliminates cross contamination due to sample bumping and automated monitoring of temperature and pressure to prevent sample degradation.
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