EC-LC/MS opens door to greater sensitivity

ESA Biosciences has announced the release of Coulochem III Analyst Driver version 1.0, enabling the Coulochem III electrochemical (EC) system to be used as an integrated device for diverse applications within Applied Biosystems/MDS Sciex's Analyst 1.4.1 LC/MS software.

Analyst software enables users to control Applied Biosystems/MDS Sciex's mass spectrometers (MS) and other HPLC devices.

ESA's Coulochem III system, compatible with a wide variety of EC cells, can be combined with LC-MS in multiple configurations.

When used as reaction devices in series with MS, electrochemical detectors have proven very useful for studies in oxidative metabolism, degradation and reactive species formation.

This combination is of particular value in drug discovery and development.

The Coulochem III EC detector may also be used in parallel with MS for complementary detection, providing an added degree of sensitivity and selectivity.

This combination is useful for many applications including the field of metabolomics.

Once installed, the Coulochem III plug-in driver acts as a companion software application in the available devices list within Analyst software.

This allows control of the Coulochem III detector within a regulated environment using electronic records and the associated features in Analyst software.

The new driver results in seamless instrument control and processing of MS and EC data, all while maintaining the utility of the Analyst software.

Offering the widest choice of operating modes, the Coulochem III readily integrates with MS for clinical, pharmaceutical, environmental, and biological applications.

Electrochemical detection is the acknowledged standard for highly sensitive and selective detection in HPLC.

The integration of the Coulochem III with Analyst software allows the Applied Biosystems/MDS Sciex platforms to utilise this approach with single system control.