ESA Biosciences reports on a new method using its unique CoulArray II electrochemical detector that enables researchers to perform rapid oxidative stability measurements
A key parameter for the use of any compound as a drug is that of its inherent chemical stability.
This stability can include everything from a measurement of a compound's stability under oxidative conditions, to the testing of a compound under artificial 'forced degradation' conditions.
The ESA methodology describes using the CoulArray II system to perform a wide variety of single electron oxidation reactions for predicting the oxidative stability of a compound under one or more different conditions.
These assays, which closely mimic the natural oxidative degradation of compounds, can be conducted in only a few seconds per sample.
Determining the relative stability of a compound or a formulation to oxidation has traditionally been a laborious and time-consuming process involving methods such as peroxide oxidation, elevated oxygen tension, or sophisticated forced degradation studies.
Because of the nature of these types of studies, they have typically not been done until later in the drug development process.
The CoulArray II is demonstrated to rapidly screen a large number of compounds for their relative stabilities enabling researchers to utilise this valuable information much earlier in the drug discovery process.
The CoulArray II is an excellent tool for high throughput measurement allowing researchers to gather important information about a compound's inherent stability and make earlier and better decisions about a compound's suitability for development.
This can have a major impact on both synthetic and medicinal chemistry efforts in any pharmaceutical company.
