Determination of enzyme activity or the monitoring of the release kinetics of antacid drugs requires a titrator that rapidly adjusts a predefined pH value and keeps it constant over a long time period
The 842 Titrando expands the Titrando system by adding the modes pH Stat titration and controlled dosing.
The new instrument thus closes the gap that existed up to now between the Titrino and Titrando systems regarding titration and measuring modes.
Stat titration.
The determination of the activity of an enzyme or the monitoring of the release kinetics of antacid drugs requires a titrator that rapidly adjusts a predefined pH value and keeps it constant over a long time period.
The 842 Titrando's controller has been optimised for this task and is among the best available on the market, says Metrohm.
It can also be used to determine the kinetics of acid-base or redox reactions.
Tandem dosing is a new feature offered by the 842 Titrando.
To avoid a break in dosing when the buret is refilled, a second buret takes over the dosing operation without any interruption.
This means that fast reactions and those that have a high reagent consumption can be monitored without any loss of accuracy.
Expanded evaluation criteria allow to determine dosing rates and thus the reaction rate over the whole measuring period or within predefined time windows.
Fixed endpoints for the measured quantities, that is for volume, time and measuring value, are also available.
The tasks to be performed in the synthesis laboratory differ from those in titration.
Typical synthesis work involves maintaining a constant pH value or performing a multiple dosing operation under strictly defined conditions: A preset volume has to be added to a solution during a given time span.
During the controlled dosing procedure, the parameters pH (or potential) and temperature are continuously monitored and registered.
This results in a complete documentation of the synthesis sequence.
Dosing can also be carried out continuously in the tandem mode with two Dosinos.
This converts the 842 Titrando into a chemically resistant high-precision pump.
When a monitored parameter infringes the set limit values, it is up to the user to decide whether to continue the dosing or interrupt and restart it manually or automatically, again applying Automatic titration with the 842 Titrandolimit values.
A new feature of the 842 Titrando is its ability to perform control tasks.
External instruments can be controlled by means of freely programmable TTL signals or by communication via RS 232 interface.
This opens up the possibility of remotely controlling external heating or cooling apparatus, pumps or similar devices.
