Varian has launched two new Top (trityl-on oligonucleotide purification) products, Top-DNA and Top-RNA, for the purification of synthetic oligonucleotides (oligos)
Synthetic DNA and RNA oligos are used by life science researchers to study the functions of genes and proteins within cells.
For oligos to work properly, salts and incomplete products need to be removed from the synthesis mixture.
Both Top products allow full length oligos to bind to the sorbent bed while salts, incomplete oligos and other impurities are washed away.
Subsequent cleavage of the protective dimethoxytrityl (trityl) groups releases the purified completed product.
Purification and de-tritylation within the Top cartridge results in higher yields and greater purity of synthesized product in less time than with alternative methods.
Top-DNA is designed to purify both short and long DNA oligos using a common method.
Top-RNA is a complete solution that includes cartridges and proprietary buffers specifically for RNA oligos.
"Top-DNA and Top-RNA extend the Top line of products," said Martin O'Donoghue, senior vice president, scientific instruments, Varian.
"Varian's Top products make it easier for the synthesisers of oligos to deliver more products to their customers in less time."
