ChromSolutions will distribute the Armen Instruments range of centrifugal partition chromatography (CPC) instruments in the UK and Ireland
Armen instruments specialises in the manufacture of preparative and industrial scale instrumentation that can operate in either low or high pressure modes.
Armen Instruments has now developed a new range based on liquid / liquid chromatography.
Much of the hardware used is relevant to both HPLC and CPC, however the fundamental differences between the two techniques is the nature of the stationary phase.
CPC chromatography does not require a silica support, instead two non miscible phases are used one phase acts as the mobile phase while the other is the stationary phase maintained in place by centrifugal force.
The affinity of the solute for each phase, measured by their partition coefficient, determines the order of elution.
In CPC there are no columns to replace or silica to recycle and solvent consumption is low which mean operating costs for preparative and industrial scale systems can be significantly reduced.
Since separation and purification is not based on interactions with a silica support, some potential harmful interactions between valuable and desired isolates and silica are avoided.
Sample losses due to irreversible binding and denaturation are also eliminated thus enhancing yield and overall purity.
The solvent system in CPC can also be changed very quickly to suit a wide and diverse range of sample types from the purification of petroleum products to peptides.
The system is also a true moving bed one with continuous injection if required.
Preparative purification can be carried out from low gram to kilogram scales.CPC technology has been accepted and adopted by the pharmaceutical,nutraceuticals,cosmetics and petroleum industries.
Applications are diverse and include purification of natural substances, essential oils, chlorophylls, lipids , antibiotics from fermentation broths, polyphenols.
With regard to biotechnology CPC systems are ideal for the purification of peptides, proteins and monoclonal antibodies.
