With the LSM 710 laser scanning microscope, Carl Zeiss says it is defining new standards for sensitivity and flexibility in examining fluorescent biological specimens
The LSM 710 Laser Scanning Microscope is described as a further milestone which Carl Zeiss is setting in its Sound of Science market launch campaign.
Much like the breakthroughs achieved in music by advances in musical instrument design, the technical innovations of the LSM 710 provide new possibilities in research conducted with living, multi-labelled cells.
With increased sensitivity with a higher signal-to-noise ratio, improved flexibility for new fluorescence dyes and multimodal experiments as well as new multiphoton detectors for deeper optical penetration into biological structures, the system can give new impetus to all areas of biological research.
Further hallmarks of the LSM 710 are its unique precision and reproducibility as well as its markedly easier operation.
Confocal fluorescence microscopy with the LSM 710 becomes much more efficient, easier and faster thanks to numerous technological innovations in the optical and electronic design and the software architecture.
The system's outstanding sensitivity ensures high-contrast, detailed images even of complex specimens such as thick, living tissue samples.
The new illumination and detection design provides absolute freedom in the selection and simultaneous imaging of up to ten fluorescence signals.
The basis is a filter-free spectral detection unit, which can be continuously set over the entire wavelength range, for the simultaneous imaging of up to ten dyes.
Innovative analysis methods such as integrated image correlation spectroscopy make it possible to extract quantitative information about molecule concentrations and mobility directly from the confocal images recorded.
Further excellent benefits of the LSM 710 include the PTC laser design, which no longer requires a laser module and enables flexible combinations and fast upgrading of various lasers from near UV to the IR range.
The innovative TwinGate main beam splitter concept supports up to 50 laser line combinations, features individually exchangeable filters and offers unparalleled suppression of the excitation laser light for brilliant, high-contrast images.
The new Quasar detector, configured with two, three, or 34 channels, is more sensitive and flexible than any previous detector system and offers spectral resolution of up to 3nm.
A spectral recycling loop increases the efficiency of the spectral splitting of fluorescence light emitted by the sample to almost 100%.
Automated software tools for system calibration and the control of the central performance parameters are always available to users and ensure that the LSM 710 operates in the optimum performance range at all times.
The Smart setup function of the Zen 2008 software, a tool for dye-centered instrument configuration, is another system highlight which makes image acquisition faster and easier than ever before.
The LSM 710 Laser Scanning Microscope can be combined with upright and inverted Axio microscope stands from Carl Zeiss.
