Bayer Schering Pharma AG in Berlin will be one of the first users of the Xcelligence system for real-time, non-labelled cell analysis from Roche Applied Science.
The Xcelligence system is designed for a range of applications spanning from short-term kinetic analysis to assays for cell proliferation and cytotoxicity.
Measurement with the Xcelligence is performed label free and allows a continuous analysis of effects and their kinetics - the system needs less than 15 seconds to analyse a 96 well E Plate.
At the heart of the technique is a micro-electronic biosensor that is built into each well of the standard 16 or 96 well E Plate microtiter plates.
A cell that has contact with the sensor changes the electrical impedance between the microelectrodes.
Each change in the cell's status leads to changes in the impedance measurements and can therefore be easily and quickly detected in real time.
Labelling of the cells, which can induce non-physiological changes in the cells, is not necessary.
