Using a 809 Titrando in conjunction with the 800 Dosino dosing system the titration of sodium bicarbonate can be carried out fully in accordance to the pharmaceutical standard CFR 21 Part 11.
Aspirin, sodium bicarbonate and citric acid combination is used to relieve pain occurring together with heartburn, sour stomach, or acid indigestion.
The aspirin in this combination is the pain reliever, while the sodium bicarbonate in this medicine is an antacid.
It neutralises stomach acid by combining with it to form a new substance that is not an acid.
The combination may also be used to lessen the chance of heart attack, stroke, or other problems that may occur when a blood vessel is blocked by blood clots.
The aspirin in this medicine helps prevent dangerous blood clots from forming.
However, this effect of aspirin may increase the chance of serious bleeding in some people.
This ratio is critical, and slight increases or decreases of one or more components can have catastrophic affects.
Aspirin level is typically determined using UV.
The sodium bicarbonate, on the other hand, is determined by a non-aqueous titrimetric method using perchloric acid as the titrant and glacial acetic acid as the solvent.
The basic unit of a Metrohm Titrando system consists of a titrator with one measuring interface that can be expanded.
The Titrando system is entirely oriented towards quality management according to GLP, GMP and 21 CFR Part 11.
As the dosing elements play a crucial role in titration the dosing units have a data chip from which the Titrando automatically reads all the data that it needs to carry out the titration properly.
Using a 809 Titrando in conjunction with the 800 Dosino dosing system the titration of sodium bicarbonate can be carried out, which is controlled using the full colour 840 touch control.
The titration takes place in a completely sealed vessel, where the glacial acetic acid is added accurately using a second Dosino.
After the titration the whole contents of the titrated solution is aspirated to waste using the second bidirectional port of the Dosino.
A solvent blank is performed and this is automatically stored by the Titrando and then used in the subsequent calculation of the sodium bicarbonate concentration.
The indicator electrode used is the Metrosensor Solvotrode combined pH glass electrode with easy-to-clean diaphragm, which is designed specifically for demanding titrations.
Whole tablets can also be analysed by smashing up the tablet in situ using an in built homogeniser.
