Waters has announced that Xenotech has begun offering metabolite profiling services made possible by its recent acquisition of a Waters Synapt high-definition mass spectrometry (HDMS) system.
The Synapt HDMS System allows Xenotech to offer services to companies that are investigating promising new drug candidates.
Integrated with a Waters Acquity ultra performance liquid chromatograph (UPLC) the Synapt HDMS system will provide Xenotech's scientific consultants with in vitro drug metabolism study data to support clients' drug discovery decision-making process, offering them insights into the viability of potential drug candidates prior to their introduction into clinical trials.
Xenotech purchased the Synapt HDMS system after a six-month evaluation of the offerings of all commercial instrument providers.
Paul Toren, director of drug metabolism and analytical chemistry at Xenotech, said: 'We needed flawless high resolution and accurate mass.
'We were impressed with the integrated software and work-flow, and once we saw the added capabilities of the Synapt HDMS's ion mobility feature, we were convinced that this was the instrument for Xenotech's lab.' Metabolic profiling is an important and growing area of expertise for Xenotech.
Its system of in vitro metabolite profiling can alleviate the need for expensive and time-consuming pre-clinical animal studies.
Xenotech's scientists screen promising drug compounds by exposing them to drug-metabolising enzymes derived from human liver cells, or hepatocytes.
Xenotech monitors the production of metabolites that might prove toxic or interfere with the intended action of the compound or co-administered pharmaceuticals.
These studies give clients an early indication whether their drug candidate could cause adverse consequences in vivo.
Xenotech is relying on the sensitivity and the ability of the Synapt HDMS to identify drug metabolites, as recommended by the US Food and Drug Administration, and to provide its scientific consultants with reliable scientific data to make sound recommendations for clients.
