Lablogic Systems has unveiled an active counting mode (ACM) that gives radio chromatographers limits of detection for the analysis of low-level samples.
The ACM is claimed to allow radio chromatographers to analyse the samples in the same timeframe as a conventional flow-through run.
Instead of applying the same parameters to variables throughout the entire run in the conventional way, the ACM actively monitors and adjusts run conditions in real time, applying the most appropriate settings dynamically as the run progresses according to a simplified heterodyne model.
According to Lablogic, the result is an increase in limits of detection in the range of sixfold upwards, depending on the sample type and other chromatographic conditions.
Furthermore, the ACM optimises peak width and overall peak shape, which means that it is suitable for the LC techniques with very narrow peak profiles.
It also improves overall resolution, making peaks easier to identify.
The ACM replaces the need to collect fractions for offline liquid scintillation counting.
This saves time by making the whole process automatic and eliminates the risk of losing volatile metabolites during sample processing.
Lablogic's ACM is compatible with HPLC system configurations.
It is available with the IN/US Beta-RAM 5 and as an add-on to the existing IN/US Beta-RAM 4 online radio HPLC flow-through detector, as well as Lablogic's GxP-compliant Laura software.
