The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis was the objective of a 2006 publication in Arteriosclerosis, Thrombosis, and Vascular Biology.
The publication is entitled 'Cholesteryl Ester Transfer Protein Decreases High-Density Lipoprotein and Severely Aggravates Atherosclerosis in APOE*3-Leiden Mice' by Marit Westerterp, Caroline C van der Hoogt, Willeke de Haan, Erik H Offerman, Geesje M Dallinga-Thie, J Wouter Jukema, Louis M Havekes and Patrick CN Rensen.
In the publication, the authors evaluated the effect of human CETP expression on atherosclerosis in APOE*3-Leiden Mice with a humanised lipoprotein profile.
Plasma Apo AI concentrations were determined using a sandwich enzyme-linked immunosorbent assay (ELISA) with Meridian Life Science (Biodesign International) Purified Mouse Apo AI as a standard.
Marit Westerterp et al concluded that CETP expression in E3L mice shifts the distribution of cholesterol from HDL to VLDL/LDL, reduces plasma-mediated SR-BI-dependent cholesterol efflux, and represents a clear pro-atherogenic factor in E3L mice.
