Metrohm is offering its Titrando system, consisting of a titrator with one measuring interface that can be expanded.
The Titrando system is entirely oriented towards quality management according to GLP.
GMP and 21 CFR, part 11.
As the dosing elements play a crucial role in titration, the dosing units have a data chip from which the Titrando automatically reads all the data that it needs to carry out the titration properly.
Using a 809 Titrando in conjunction with the 800 Dosino dosing system, the titration of sodium bicarbonate can be carried out fully in accordance to the pharmaceutical standard CFR 21, part 11.
All of this is controlled using the full-colour 840 Touch Control.
The titration takes place in a completely sealed vessel, where the glacial acetic acid is added accurately using a second Dosino.
After the titration, the whole contents of the titrated solution is aspirated to waste using the second bidirectional port of the Dosino.
A solvent blank is performed and this is automatically stored by the Titrando and then used in the subsequent calculation of the sodium bicarbonate concentration.
The indicator electrode used is the Metrosensor Solvotrode combined pH glass electrode with easy-to-clean diaphragm, which is designed specifically for demanding titrations.
Whole tablets can also be analysed by smashing up the tablet in situ using an inbuilt homogeniser.
This sample preparation can be automated with the 789 Robotic Sample Processor XL.
In this case, the homogeniser is mounted on a swing head with robotic arm, which makes the processing of large series of samples in multi-row racks possible.
