Corning Incorporated and Geron have announced the development of novel synthetic surface matrices that enhance and support the scalable manufacturing and growth of human embryonic stem cells (hESCs).
Through its ongoing collaboration with Geron, Corning has developed a synthetic surface that supports the growth and differentiation of hESCs in a defined (animal-free) medium.
Data presented at the World Stem Cell Summit in Baltimore will show multi-passage growth of multiple undifferentiated hESC lines and the subsequent differentiation of one of these cell lines into cardiomyocytes.
The growth and differentiation of hESCs on this surface is robust and reproducible, an important condition for the large-scale production of cells and therapeutic development.
Data will specifically be presented in a poster titled, 'Synthetic Peptide-Acrylate Surfaces for Long-Term Self Renewal and Cardiomyocyte Differentiation of Human Embryonic Stem Cells in Defined Medium.' Synthetic growth surfaces could replace widely used biological surface coatings to grow and differentiate pluripotent stem cells and may offer increased reproducibility, cost savings, and regulatory advantages.
