Freeman Technology is to highlight its FT4 powder rheometer and the insight that it can offer DPI formulators at Respiratory Drug Delivery (RDD) 2010 on 25-29 April.
This will be reinforced by a presentation of work from the University of Bath showing a direct correlation between the measured dynamic powder properties and fine particle dose (FPD), a measure of drug delivery efficiency.
Dynamic powder characterisation with the FT4 directly quantifies powder flowability and the response of a formulation to air, a critical property for successful DPI development.
To ensure efficient drug delivery a DPI formulation/device combination must be engineered to achieve aerosolisation of the dose to a respirable size during use.
Research at the University of Bath has shown a robust correlation between FPD and aerated energy, a measure of how the flowability of the powder changes with the amount of air flowing through it.
This is said to make the FT4 a useful tool for the development of DPI formulations, which are required to disperse easily, with more consistent and less patient-dependent performance.
The FT4 combines dynamic testing methodologies with shear and bulk property measurement, to provide comprehensive, process-relevant powder characterisation.
Precision engineering in combination with well-defined, automated test procedures deliver good reproducibility and sensitivity.
