Bio-Rad Laboratories has released the ProteOn HTE Sensor Chip for studying the interaction of polyhistidine-tagged protein with small molecule drugs using surface plasmon resonance.
The chip's tris-NTA coated surface uses three NTA molecules instead of the traditional monomer version of the molecule which yields a stronger binding interaction with the target, resulting in improved data quality compared to other biosensor solutions for capturing polyhistidine-tagged targets.