Screening technique aids discovery of bacteria-resistant materials

Researchers at Nottingham University have discovered a new class of polymers that are resistant to bacterial attachment. These new materials could lead to a significant reduction in hospital infections and medical device failures.

Medical device associated infections can lead to systemic infections or device failure, costing the NHS £1bn a year. Affecting many commonly used devices including urinary and venous catheters – bacteria form communities known as biofilms.

The research was led by Professor Morgan Alexander, and Professor Martyn Davies in the School of Pharmacy and Professor Paul Williams in the School of Molecular Medical Sciences.

The novel materials had to be found using a new technique

Researchers believed there were new materials that could resist bacteria better but they had to find them. This meant screening thousands of different chemistries and testing their reaction to bacteria – a challenge which was beyond conventional materials development or any of our current understanding of the interaction of micro-organisms with surfaces.

The discovery has been made with the help of experts from the Massachusetts Institute of Technology (MIT) – who initially developed the process by which thousands of unique polymers can now be screened simultaneously.

Professor Alexander said: “The technology developed with the help of MIT means that hundreds of materials could be screened simultaneously to reveal new structure-property relationships. In total thousands of materials were investigated using this high throughput materials discovery approach leading to the identification of novel materials resisting bacterial attachment. This could not have been achieved using conventional techniques.”

These new materials prevent infection by stopping biofilm formation at the earliest possible stage – when the bacteria first attempt to attach themselves to the device. In the laboratory experts were able to reduce the numbers of bacteria by up to 96.7per cent – compared with a commercially available silver containing catheter – and were effective at resisting bacterial attachment in a mouse implant infection model.

By preventing bacterial attachment the body’s own immune system can kill the bacteria before they have time to generate biofilms.

The next stage of this research will be to develop the manufacture of these coatings to enable the performance of these materials to be assessed clinically and the inventors are in early stage discussions with a number of medical device companies.