Evaluation of these whole chromosome painting probes in leading laboratories has shown that they provide superior chromosome coverage when compared to competitive or in-house generated probes
Cytocell Technologies, a provider of innovative screening solutions for human genetic analysis, has launched a comprehensive range of whole chromosome painting probes available in Aquarius liquid format.
These new products are available directly labelled in either a red or a green fluorophore (Texas Red or FITC spectra respectively).
They can be mixed together to label a number of chromosomes in a single reaction.
The probes come ready to use in hybridisation solution, in an economical five test kit format and are supplied complete with Dapi counterstain.
The protocol is rapid and simple and follows simultaneous co-denaturation of the Fish probe and target DNA. Evaluation of these whole chromosome painting probes in leading laboratories has shown that they provide superior chromosome coverage when compared to competitive products or in-house generated probes.
Cytocell's whole chromosome painting probes consist of libraries of DNA sequences derived from flow-sorted chromosomes.
These libraries contain sequences stretching over the entire length of the chromosome and provide superior coverage of each human chromosome.
Applications include analysis of chromosome partners involved in translocations; identification of the chromosome of origin of marker chromosomes; confirmation of results obtained from M-Fish and Sky testing and may be of particular interest to those studying mutagenesis of human chromosomes as a result of exposure to genotoxic agents. The probes are designed for use in fluorescence in situ hybridisation analysis of human metaphase chromosomes from cultured peripheral blood cells.
Commenting on the launch of the new products, Cytocell's managing director Martin Lawrie said: "These new probes provide a long-awaited solution to customers unhappy with their existing painting probes.
"I am delighted that they have already shown superior signal strength and chromosome coverage, they will be a valuable addition to Cytocell's already comprehensive product portfolio".
