A new assay for the quantitative determination of Ceruloplasmin in human serum and plasma has been introduced for use on Olympus analysers
A new assay for the quantitative determination of Ceruloplasmin in human serum and plasma has been introduced for use on Olympus analysers.
The CE marked product, OSR 6164, has linearity from 60 to 2000mg/l.
Calibrator and control sera materials are available to support this.
Available in a kit size of four x 18ml (reagent 1) and four x 5ml (reagent 2) with an on-board stability of 60 days and calibration stability of 14 days, the assay exhibits exceptionally good haemolysate, bilirubin, and lipaemic interference characteristics.
Those attending the 2003 Olympus User Group meeting will have learned how human ceruloplasmin 'ages' in the sample - the shape of the molecule changes over the first few days after sample collection and this results in a change in the antibody binding sites.
It is therefore recommended that analysis ideally occurs on the same day the sample is collected.
Ceruloplasmin is a primary copper transporting protein in plasma, and is a late acute phase reactant synthesised by the liver.
The main clinical importance of Ceruloplasmin is in the diagnosis of Wilson's disease.
