New service promises significant time savings in chemistry development within drug discovery
Personal Chemistry has announced the provision of a new microwave scale up service offering significant time savings in chemistry development within drug discovery.
In response to the demand for Personal Chemistry's unique microwave scale-up technology, professional scale up services will now be available from Personal Chemistry as a complement to its state-of-the-art products.
In recognition of the company's role as the market leader in microwave assisted organic synthesis, several major pharma companies have already approached Personal Chemistry for help in scaling up their promising and unique compounds developed using Personal Chemistry's Coherent Synthesis platform. Personal Chemistry can offer both the in-depth knowledge of organic chemistry (over 30 % of the 100 employees are chemists, many at the PhD-level) and the best available technology needed to support the customers' scale up efforts.
Altana Pharma has already benefited from Personal Chemistry's scale up technique, which has helped them synthesise 220g of a specific substance.
A significant amount of time was saved due to the fact that the reaction parameters from the smaller scale instrument, Emrys Creator, could be transferred directly into larger scale. The conditions were thus scalable and there was no need for further optimisation.
"The scale-up system worked excellently and we received the same or even better results compared to the small scale reactions.
The whole process was also completed in a fraction of the time we would normally spend using traditional methods." said Josef Stadlwieser, head of combinatorial chemistry at Altana Pharma.
"This technique can really improve both speed and productivity when scaling up new substances.
It is a valuable opportunity to be able to scale-up so rapidly on a contract bases." There are multiple benefits to be gained by scaling up substances with the new Coherent Synthesis scale up technique.
It is possible to safely speed up reactions between 10 to 1000 times and the increased yield and purity of the substances that is usually achieved also makes the work-up and purification much easier and quicker - a benefit which is further amplified in larger scales.
Several studies have proven the excellent direct scalability that exists within the Coherent Synthesis platform: it is possible to optimise reactions on Personal Chemistry's small-scale instruments (Emrys Creator, Emrys Optimiser, or Emrys Synthesiser) and then directly and safely apply the same reaction parameters to a reaction scaled up more than 50 times and still get the same results.
Other benefits include the possibility to use greener chemistry also in larger scales and to find new, interesting reaction routes that were previously inaccessible. The high reproducibility achieved with this technique makes it especially suitable for many kinds of chemistry, for example building blocks.
