Image analysis system automates protein array studies to offer a rapid method of analysing potential anti-cancer drugs at a major pharmaceutical company
Syngene reports that its ChemiGenius2 image analysis system is being used at a major European pharmaceutical company to automate protein array studies of anti-cancer molecules.
Researchers at the company are using the ChemiGenius2 to detect and analyse the effects that potential therapeutic compounds have on human chemokines and cytokines in a 96-well protein array format. Following a typical sandwich Elisa, light is generated with a chemiluminescent substrate and imaging the entire plate with a ChemiGenius2 captures the light produced at each array spot.
The array data is then automatically analysed using GeneTools image analysis software, which comes as standard with a ChemiGenius2. The ChemiGenius2 is helping to quickly determine which molecules have potential as anti-cancer agents and so far, researchers at the company have found that the human chemokines arrays provide the best results.
According to researchers at the pharmaceutical company, the system was chosen because it images an array pattern with good sensitivity and is simple to operate.
Its performance for array detection is better than other systems the company evaluated and it is less expensive than a laser-based scanner. Laura Sullivan, Syngene's divisional manager commented: "We are excited to see the ChemiGenius2 being used at a well-respected pharmaceutical company for automating protein array detection in the vital area of cancer treatment.
"This is a major new application of the ChemiGenius2, which it handles with ease, demonstrating the accuracy and flexibility the system offers for proteomics research."
