Manual electrode for Teer measurements using high throughput screening plates from several major cell culture insert manufacturers
With the development of a high throughput screening (HTS) protocol for faster drug discovery, a new line of cell culture filter plates have been introduced by several major cell culture insert manufacturers.
In response to these developments, World Precision Instruments has developed a manual electrode, STX100, for Teer measurements using HTS plates.
STX100's design is based on the same reliable design principle as the universally used STX2 electrode, with several important modifications.
The size of the electrode tip has been reduced to 1.5mm to facilitate positioning through the narrower slit of the HTS plate.
The STX100 electrode itself is constructed using a stronger material for higher durability and maximum usage applications.
The bottom section of the electrode is shaped to fit neatly into the keyhole-shaped filter well.
This enables the STX100 electrode to measure TEER with increased accuracy and reproducibility compared to the standard STX2.
Several versions of STX100 are available, designed to fit the Corning Costar 24-well HTS plate, the Falcon 24 well HTS plate, the Millipore Multiscreen CaCo2 96-well plate, and BD Falcon HTS 96-multiwell plate.
Measurement can be directly performed when the HTS plate is in either a common or divided tray, reducing the possibility of contamination as well as mechanical damage to the cultured cells.
