National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) scientists analyse HuCAL-based mini-antibodies as a potential basis for future HIV-1 therapeutics
Antibodies by Design announces the publication of a scientific research paper from a customer using antibodies generated from the MorphoSys HuCAL Gold antibody library.
Using its rapid, high-throughput antibody generation system, Antibodies by Design selected a set of eight monoclonal and fully human mini-antibodies targeted specifically against the HIV-1 protein gp41 antigens provided by Dr G Marius Clore.
Scientists working in the team of Drs Clore and Bewley at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) - part of the US National Institute of Health (NIH) - subsequently analysed these antibodies in detail and published the results in the current edition of the Journal of Molecular Biology.
The analysis demonstrates that the HuCAL-based antibody fragments provide a set of useful probes for studying HIV-1 envelope-mediated cell fusion and may act as fusion inhibitors preventing HIV-1 virus particles from entering their target cells.
