Shimadzu Scientific Instruments has published the application note, 'Real time in-situ monitoring of organic reactions using an FTIR fiber optic system'
The formations of intermediates in chemical reactions play integral roles in the final result of the chemical reaction.
Often, these intermediates cannot be monitored in real time and even in cases where it is possible to trap or isolate the intermediate, its characterisation and determination of purity and yield can consume many hours.
The use of the FTIR as a reaction monitor can aid in recognising formation of intermediates as well as in determining depletion of reactants and formation of products.
In most cases, it is not feasible to remove aliquots of a reaction mixture for measurement with traditional IR accessories such as liquid cells.
The use of a fibre optic probe system allows real-time monitoring of the reaction in the reaction vessel.
In this communication, a system is described that allows real-time monitoring of chemical reactions at elevated or sub ambient temperatures without jeopardising the reaction system.
It shows that FTIR is a viable way of monitoring an organic reaction in real-time where there are discernable differences in functional groups between reactants and the products.
The use of a fibre optic probe can enhance this capability by enabling monitoring of the reaction in-situ.
