BIOSTAT single use biorector launched by Sartorius
30 Apr 2017
Sartorius Stedim Biotech has launched of its next generation BIOSTAT STR - a fully scalable, single-use bioreactor family based on a conventional stirred-tank design.
The new bioreactor range features upgraded hardware and software, as well as a fully integrated, new design of Flexsafe STR single-use bags for quick and easy bioprocess scale-up of biologics and vaccines.
Dr. Thorsten Adams, Director of Product Management for Fermentation Technologies at Sartorius Stedim Biotech, said: “Direct linear scalability is crucial for ensuring the efficiency and costeffectiveness of bioprocess development campaigns. Compared with conventional stainless steel vessels, our next generation BIOSTAT STR bioreactors in combination with the ambr 250 technology will help reduce process development timelines significantly. These highly scalable, single-use bioreactors are an intelligent, low-risk bioprocess development solution for use in multi-product facilities, as well as at contract manufacturing organisations, for the production of biologics and vaccines.”
Improved stainless steel bag holder for user friendly installation of the single-use Flexsafe STR bag.
Series of five systems in different sizes offering working volumes from 12.5 L to 2,000 L.
Designed with the same geometries as SSB’s ambr 250 mini bioreactor, enabling linear scale-up and process transfer from 250 mL to 2,000 L to be achieved in weeks rather than months.
Single-use Flexsafe STR bags with advanced single-use sensor solutions are manufactured from a proprietary, robust multilayer S80 polyethylene film. The formulation of resins and additives for the film are fully characterised, and extrusion process parameters are controlled within established ranges, providing consistent batch-to-batch extractable and leachable profiles.
As well as using bags of the highest purity, the system is designed for efficient oxygen transfer, mixing and CO2 stripping.
Software connectivity has been upgraded to allow integrated control by either BioPAT MFCS software or commonly used third-party industrial distributed control systems (DCS), such as Emerson DeltaV or Siemens SIMATIC PCS7.