Waters has released the Waters Synapt G2 System for qualitative and quantitative quadrupole time-of-flight mass spectrometry.
The Synapt G2 System features new Quantof and enhanced high-definition MS technologies.
It provides researchers with intuitive operation and application flexibility.
It is suitable for use with biopharmaceutical, metabolite identification, metabonomics, proteomics, biomarker studies and food and environmental applications.
The Synapt G2 System can provide in excess of 40,000 FWHM resolution, class-leading sensitivity, a data-acquisition rate of 20 spectra/second, exact mass (1ppm RMS) information and a dynamic range of up to five orders of magnitude.
The Waters Synapt G2 Mass Spectrometer can be paired with Waters Acquity Ultraperformance LC (UPLC) technology.
The Synapt G2 System features Quantof technology, which combines a high field pusher and dual-stage reflectron with a novel ion-detection system in an optimised, folded, TOF geometry.
These features provide a new dimension of high resolution, exact mass and quantitative performance available at acquisition rates compatible with UPLC separations.
It means scientists don't need to compromise mass resolution when they want chromatographic resolution and high speed, selectivity and specificity.
Quantof's high field pusher and dual-stage reflectron reduce ion turnaround times associated with pre-push kinetic energy spread; the dual-stage reflectron also improves focusing of high energy ions.
Synapt G2's ion-detection system combines an ultra-fast electron multiplier with hybrid ADC detector electronics to provide outstanding qualitative and quantitative performance for MS for the elevated data-acquisition rates of HDMS analysis.
Integrated second-generation Triwave Technology, the ion mobility resolving power of the Synapt G2, is up to four-times higher than the original Synapt system.
This means scientists can easily separate similar sample components - based on size, charge, mass and shape - and identify sample components that might previously have been invisible to them.
Quantof technology provides facile exact mass measurement and enhanced dynamic range for IMS/MS experiments, resulting in the highest coverage and confidence for novel discovery analyses.
The Synapt G2 features Driftscope Mobility Environment Software (v2.1), which helps it detect components, reveal new or subtle features in the data and provides more efficient data-processing workflows such as the measurement of a compound's collisional cross-section (shape).
This allows scientists to make new discoveries while reducing the time needed to deliver business and research-critical information.
The Synapt G2 incorporates Intellistart technology, which calibrates and prepares the instrument for operation while continually monitoring its performance.
It can automate set-up procedures, minimise the opportunity for human error and make the mass spectrometer more accessible to those who may be new to mass spectrometry yet need to consistently generate high-quality results.
To maximise the number of experimental options and research applications, Waters offers a choice of UPLC inlet technologies and universal ion sources for the Synapt G2.
These comprise the Nanoacquity UPLC and Trizaic UPLC inlets and ion sources, including: electrospray (ESI), nanoflow ESI, atmospheric chemical ionization (APCi), combined ESI/APCi (ESCi), atmospheric solids analysis probe (ASAP), and atmospheric pressure gas chromatography (APGC).
The same ion-source options are compatible with the Waters Xevo TQ and Xevo QTof mass spectrometers.
The interchangeable design of the APGC source for the Synapt G2 System allows scientists to perform GC/MS and LC/MS experiments on the same instrument.
The Synapt G2 removes the need for laboratories to dedicate separate mass spectrometers for LC/MS/MS or GC/MS/MS work.
Waters also offers a high performance, exchangeable Maldi source for the Synapt G2 System.
For example, by combining Maldi with ion mobility separations, the Waters High Definition Imaging Maldi (HDI Maldi) solution enables researchers to better determine the localisation of metabolites and active drug compounds in tissue samples.
Waters offers application managers for its Masslynx MS software that allow the Synapt G2 to perform tasks including screening, de-convolution, identification, target quantification, qualitative and quantitative profiling and characterisation - and transform acquired data into useable results.
In addition to the Synapt G2 with full HDMS capabilities, scientists have a choice of HDMS-ready products including the Synapt G2 MS and Maldi Synapt G2 MS, which can be upgraded on site to maximise the full potential of second-generation HDMS functionality.