Waters has introduced two mass spectrometers for its Xevo MS platform - the Xevo TQ-S and Xevo G2 QTof.
The product introductions were made at the 58th annual meeting of the American Society for Mass Spectrometry (ASMS).
Combined with Waters Acquity Ultraperformance LC (UPLC) Systems, these mass spectrometers offer scientists a combination of separations power with high levels of sensitivity, whether for compound identification, quantification and screening, or for extracting the most information from the smallest sample volumes all in a single analysis.
The Waters Xevo TQ-S tandem mass spectrometer is said to represent a step change in targeted quantitative UPLC/Multiple Reaction Monitoring (MRM) analysis.
The system is capable of accurately measuring target compounds in complex samples at femtogram levels or below.
The Xevo TQ-S is designed for UPLC/MS/MS applications such as biological and medical research, bioanalysis, food safety, environmental monitoring and forensics testing where speed, sensitivity and accuracy are of importance.
It features Stepwave ion-transfer technology, an off-axis design for increasing the efficiency of ion transfer from the ion source to the quadrupole MS analyser, while at the same time actively eliminating undesirable neutral contaminants.
When compared to earlier-generation mass-spectrometer models, the chromatographic peak areas are said to be typically more than 30 times larger and the signal-to-noise ratios are typically five to 10 times better.
The novel, high-speed transfer optics and collision cell design allows the TQ-S system to acquire full scan MS and MRM data simultaneously on narrow, 1-2sec wide UPLC peaks and still obtain more than 12 points across the peak.
The instrument's sensitivity also allows scientists to consider diluting samples in order to reduce matrix effects that interfere with compound measurements.
They can also work with smaller sample volumes - a benefit when analysing biological samples taken from animals or humans.
Xevo G2 QTof is a benchtop exact-mass MS/MS mass spectrometer and the first Xevo time-of-flight mass spectrometer to feature Waters Quantof technology - currently only available with Waters' Synapt G2 MS and G2 HDMS Mass Spectrometers.
This technology brings research-grade quantitative and qualitative analytical performance to research, academic and industrial laboratories.
Quantof technology can extend the dynamic range of previous-generation Xevo QTof systems to greater than four orders of magnitude and results in much higher mass resolution for greater efficiency and productivity in the laboratory.
Combined with Waters' Acquity UPLC System, the Xevo G2 QTof leverages the power of UPLC/MS(E) - a simple method of data acquisition that comprehensively catalogs complex samples in a single analysis.
This gives scientists a comprehensive digital record of the sample that can be re-interrogated at will, eliminating the need to re-analyse the sample.
The Xevo G2 QTof is designed for labs driven by the need to produce accurate quantitative and qualitative information on increasingly large numbers of samples when doing intact protein analysis, peptide mapping, oligonucleotide analysis, metabolite identification, metabolite profiling, proteomics experiments and food-safety screening.