Atlas Biolabs has introduced Sequenom's Massarray analyser for use in DNA analysis, expanding its range of services in molecular genetics.
The Massarray system comprises a high-throughput platform that utilises matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (Maldi-Tof) for genotyping of single nucleotide polymorphisms (SNPs).
The system can be used for validating potential biomarkers identified by next-generation sequencing, for fine mapping of genome-wide association study (GWAS) data and for applications that employ defined SNP panels.
The flexibility of the system is said to allow for the quick adoption of newly discovered biomarkers into novel or existing biomarker panels.
Mass spectrometry requires only very small amounts of genomic DNA and delivers precise quantitative results, thereby providing benefits for the analysis of genetic material.
With the direct detection method it is possible to find even low-frequency mutations that might otherwise go undetected.
Moreover, genotyping can be carried out with fresh and frozen material and also with formalin-fixed, paraffin-embedded (FFPE) tissue samples.
Since DNA purified from FFPE material is usually highly degraded and available only in small quantities, the molecular analysis of these samples is limited when using convention methods.
Maldi-Tof is said to be valuable in SNP genotyping following GWAS.
In addition, by combining the Massarray system with Sequenom's Oncocarta panel, Atlas Biolabs is now able to rapidly monitor oncogene mutation in somatic cells.
