Waters has introduced the Acquity UPLC I-Class system designed for scientists undertaking difficult separations and offering low system dispersion and low carryover.
Low dispersion maximises peak capacity thereby advancing chromatographic separations and optimising the performance of any mass spectrometer.
The Acquity UPLC I-Class system is claimed to excel when analysing complex, sample-limited compounds.
Sample-limited compounds include high-potency medications, trace levels of food or water contamination, and (advanced) sophisticated biotherapeutics.
These samples can represent complex separation challenges requiring an LC system that can maximise the benefits of sub-two-micron for faster throughput and optimised mass spectrometry performance.
Minimal system volume is an important new feature of the Acquity UPLC I-Class.
This decreases dispersion rates for reproducibly higher resolution and superior peak capacity.
Reduced dispersion and small peak volumes extend the sensitivity of any mass spectrometer.
In addition, low dispersion footprint allows users to reduce their separation cycle times without impact to the separation as resolution is maintained even for ballistic gradients lasting less than one minute.
The new design and materials reduces sample carryover effects, increasing user confidence in results.
The Acquity UPLC I-Class also offers flexibility and precise sampling capabilities.
Depending on the needs of their application, users can choose either the highest-precision and lowest-dispersion fixed-loop Sample Manager; or the low-dispersion, variable-volume Sample Manager with a flow-through needle design, which delivers high-precision injections, good sample recovery, and low sample carryover.