Due to the announced closure of Transgenomic, Glasgow, Scotland, Rhys International is now brokering a new pilot plant designed for synthetic nucleic acids
This pilot plant designed for synthetic nucleic acids incorporates eight ASME VIII Div 1 S/S reactors, structural and access steelwork, all associated pipework, pumps, electrical and instrumentation work and ancillary equipment for sale.
Rhys International is able to offer new pilot plant designed for synthetic nucleic acids, details as follows:.
Segregated processing - area 375m2 (4000ft2).
Laminar flow booths.
Two IBC charging / discharging stations.
Operators protected from fugitive emissions.
Solvents measured by 'loss in weight'.
Solvents can be charged to any vessel via dedicated lines.
Acyl, trityl and phos agent reactors.
Acyl and phos 2650ltr, trityl 1400ltr capacity, all Stainless steel 316L.
Agitator (variable speed).
Jacketed acyl and trityl -30C to +170C, Phos -30C.
Overhead condenser on acyl reactor.
Solids charging facilities on acyl and trityl reactors.
Intermediate and product storage vessels: all stainless steel 316L, two 2650ltr, one 1400ltr six 170ltr.
Overhead condenser on acyl reactor for pyridine azeotroping.
Wiped film evaporator in trityl process.
Short residence time for heat sensitive product.
Can operate down to 10mbara.
Jacket temperatures up to +170C.
Wiped film evaporator in phos agent process.
Can operate down to 0.1mbara.
Jacket temperatures up to +170C.
Filter dyer.
0.3m2 filter area.
Stainless steel 316L.
Side and base heated jackets.
Controls.
+/-1C control on all heating / cooling loops.
PID controls on vacuum and evaporator feed flow.
Variable speed control on most drives.
Weigh scales in both LFBs.
Synthetic nucleic acids summary.
Core competencies in place for increased scale of phosphoramidite manufacture.
Flexible/scaleable manufacturing technology base.
Focus on being an integrated supplier of synthesis reagents and purification technologies.
Commitment to increase capabilities to meet future demand.
