Medicinal chemistry specialists Charnwood Molecular (Loughborough UK) have been using the DrySyn MAXI heating system from Asynt to successfully and reproducibly scale up syntheses within their contract research laboratories.
Dr Michael McKenzie, Head of Operations, said: “Here at Charnwood Molecular our experienced preclinical R&D team routinely investigate the development of small scale medicinal chemistry routes in order to facilitate the timely supply of up to 500g
of a final compound to our clients for testing.
Delivery of this initial key amount of compound for preclinical studies is accompanied by a new, robust and transferable scale-up route to go beyond that quantity in clinical phases. Investment in DrySyn technology has allowed us to reproducibly scale-up our customers’ synthetic reactions from the milligrams to hundreds
of grams scale."
Used with a conventional laboratory hotplate stirrer, DrySyn MAXI heating blocks are designed to provide rapid, safe and controllable heating up to 250ºC, with excellent reaction visibility and powerful stirring.
The DrySyn MAXI block accommodates any standard 3000ml round-bottom flask and - using an insert the block - is easily adapted for 2000ml flasks. Heat-resistant handles on the heating block make for greater safety and convenience when moving large flasks around the laboratory. Provision is made for a temperature probe should temperature feedback control or monitoring be required.
Using standard round-bottomed reaction flasks, the system provides safe and accurate temperature control for synthesis, distillation and reflux operations when larger volumes (up to 3 litres) are in use. For further scale-up, the DrySyn
SuperMAXI heating block is available for both 4000ml and 5000ml sized flasks.
