Restek’s new inert LC column technology helps labs improve their analysis of metal sensitive compounds. A premium inert coating applied to the stainless-steel surface of LC columns reduces nonspecific binding of chelating analytes, enabling sensitive analysis and smooth integration of peaks. Combined with Restek’s selective stationary phases, these new inert LC columns are ideal for the analysis of metal-sensitive compounds.
Restek’s inert LC columns can provide four key benefits:
- Improved peak shape without passivation or mobile phase additives.
- Increased response and analyte recovery, allowing lower detection limits.
- High accuracy and throughput with less variability.
- Less time-consuming conditioning and complicated passivation required.
Analysing compounds that have nonspecific adsorption (NSA) or nonspecific binding (NSB) to metal surfaces in LC columns have historically been a challenge. Poor peak shape and sensitivity are key indicators that polar, usually acidic compounds are interacting with the metal surfaces in the column, causing poor data quality. This premium inert column technology is designed to eliminate NSA and NSB of active analytes to the column hardware, giving analysts greater confidence in their data when working with metal-sensitive analytes such as:
Pesticides: Phosphorylated, acidic, polar compounds, and/or metal chelating species, such as organophosphate pesticides, are reactive to the metal surfaces inside of the analytical column. Restek’s inert LC columns solve this problem to improve the overall performance of your pesticide panel.
Mycotoxins: Mycotoxins analysis often requires a great deal of column conditioning and equilibration to achieve acceptable peaks due to the reactive nature of compounds which contain acidic, polar, or otherwise metal chelating groups. Restek’s inert column hardware, combined with their stationary phases, helps simplify methods and improve the response and peak shape of these compounds.
Inert LC column technology is available on three column types: Raptor Biphenyl, Raptor ARC-18, and Force Biphenyl. Learn more about Restek’s Inert LC columns.
