With the introduction of the ultra-sensitve EnzoLyte 520 Renin Assay Kit, AnaSpec now offers a renin assay kit that is 40x more sensitive than comparable kits currently in the market
The past decade has witnessed the development of a number of synthetic renin inhibitors1-3.
However, increasing demand for accelerated drug discovery and automated inhibitor screening has generated a need for a continuous, homogeneous assay with even greater sensitivity.
With the introduction of the ultra-sensitve EnzoLyte 520 Renin Assay Kit, AnaSpec now offers a renin assay kit that is 40x more sensitive than comparable kits currently in the market.
Renin, a highly specific aspartyl protease, cleaves angiotensinogen, to yield angiotensin I, which is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme).
Angiotensin II constricts blood vessels, leading to increased blood pressure.
Angiotensin II also increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex.
Since an overactive renin-angiotensin system leads to hypertension, renin is an attractive target for the treatment of this disease.
While existing renin assay kits offer sub-nanomolar potency and selectivity, AnaSpec's EnzoLyte 520 Renin Assay Kit offers picomolar sensitivity - the highest sensitivity available for commercial renin assay kits.
AnaSpec also offers a shorter emission wavelength kit, EnzoLyte 390 Renin Assay Kit - a cost-effective option that offers greater sensitivity than Edans/Dabcyl-based renin assay kits.
