Technical poster, 'High throughput cytochrome P450 inhibition assays using a Velocity11 BioCel automation solution' is available on Velocity11's website, or a copy can be obtained from the company
Velocity11 has announced the application of its BioCel automation system platform for use in high-throughput in vitro Adme/Tox assays.
A recently presented technical poster describes the automation of an in vitro cytochrome P450 assay.
Discovery of small molecule drug candidates typically involves assessment of in vitro Adme/Tox properties of hundreds to thousands of compounds.
Usually such applications require several individual automated liquid handling stations to perform the various testing protocols.
Using a Velocity11 BioCel automation system the authors describe an approach for assessing multiple compound properties rapidly and reliably.
The investigations focus upon a cytochrome P450 inhibition assay and compare data from manual and automated runs.
Using a range of eight compounds of varying potency, the robotic assay was able to produce data comparable with manual assays and with variability acceptable for screening purposes.
Considerable time saving through automation of the processes are demonstrated.
The BioCel automation system delivers the functionality of much larger systems in an efficient innovative package optimised for speed.
The BioCel is a fully capable sample-processing platform for assembling genomics reactions, dispensing samples for compound preparation, or processing biological samples in screening applications.
The system's event-driven scheduler supports multiple plate formats and labware, multiple protocols, and linear and parallel process flows, while the software architecture accommodates expansion of the system to include additional modules and access to new third party devices.
