Malvern Instruments will demonstrate an application for foreign particle determination on filters and will show systems for protein characterisation and rheology measurement at AAPS 2008.
The Morphologi G3, Zetasizer APS, Zetasizer UV and the Kinexus rheometer platform were launched in September and will be exhibited for the first time from 17-20 November in Atlanta.
A new capability on the Morphologi G3 automated particle characterisation system enables the fully automated detection, enumeration and size classification of foreign particulate matter (FPM) collected on a filter.
This is especially important in controlling particulate contamination of materials for injection or inhalation.
Analysis of FPM on filters has traditionally been the preserve of manual light microscopy.
The Morphologi G3 brings fully automated image analysis to accelerate characterisation and remove any operator subjectivity.
The Zetasizer APS is a dynamic light scattering (DLS) system that automates size measurements of samples in 96- or 384-well microplates.
Designed primarily for protein specialists, it is fully automated, requiring users to just insert the plate and press start.
The Zetasizer APS allows investigation of a protein's condition at different stages of the purification process, and at later stages of formulation under a range of environmental conditions.
The measurement technology used delivers results with exactly the same high precision and reproducibility you would expect from a research grade batch DLS system.
The Zetasizer UV is an advanced light scattering system specifically intended for the characterisation of proteins and other biomolecules.
Designed and optimised for maximum sensitivity and minimum sample volume, the Zetasizer UV is a dedicated system that supports improved understanding and management of a wide range of biomolecule applications.
The Kinexus is a rotational rheometer platform.
It enables users to spend less time learning how to interact with their system and more time investigating ways to characterise and enhance a material's performance.
Embedding expert knowledge and adaptive intelligence within the instrument delivers application-relevant and high quality data for all users, generating information that will truly add value to a product or process.
As well as supporting the exhibition, Malvern is participating in the conference.
Dr Paul Kippax, product manager for laser diffraction systems at Malvern, will contribute a paper on 'Method Development and Validation for Particle Size Measurements'.
His presentation will examine requirements for the development and validation of particle sizing methods, with reference to the FDA's guidance documentation, the US pharmacopoeia and the available international standards.
