Nikon Instruments' Perfect Focus System (PFS) has been ranked second in The Scientist's top innovations of 2008.
Nikon's PFS stops focus from drifting, one of the biggest challenges in high resolution and live cell imaging.
PFS is a hardware component that uses a half-moon shaped beam of infrared light to track optical offset and correct for it by sampling every five milliseconds.
It holds focus in time-lapse experiments and in short-term studies where acts such as perfusing a drug or moving a Z-stage may shift the sample.
It is compatible with the Ti inverted microscope series.