Malvern's Zetasizer auto plate sampler (APS) is designed primarily for protein specialists, delivering automated protein and nanoparticle size measurements using dynamic light scattering (DLS).
The Zetasizer APS does not require microwell plates to be flat-bottomed or have specific optical properties.
A sample handling process makes it compatible with virtually all commercially available microwell plates.
Automated measurement procedures using industry standard 96- or 384-well plates enable users to insert a sample plate and press start.
Malvern said the Zetasizer APS delivers accurate and repeatable protein size and molecular weight data with no compromise in data quality due to automating the measurements.
Only 20ul of sample is used, which is returned to the same well for use for other characterisation techniques.
Programmable dual temperature controls maintain optimal conditions for samples in the well plate while enabling automated temperature trend measurements for melting point determination, protein purity or shelf-life investigations, for example.
DLS data can be used to solve application problems in bioprocessing, drug target development and protein therapeutics.
DLS measures the thermal diffusion of proteins and nanoparticles in solution, and uses this property to determine an absolute hydrodynamic size.
This technique is especially sensitive to the presence of aggregates, and their proportion as a function of solvent and buffer conditions can also be determined.
