Tecan and Pion have developed automated solutions for drug permeability and solubility screening.
This follows the launch of manual assay systems for permeability and solubility.
The automated application provides scalability from an upgradeable, entry-level manual system, to a fully automated system with medium or high throughput, according to changing requirements.
Pion's Double-Sink parallel artificial membrane permeability assay (Pampa), a compound-sparing technique that helps to identify the most promising leads well in advance of cell-based methods, has been integrated with Tecan's Freedom Evo platform and Infinite M200 plate reader in the Pampa Evolution.
The system offers enhanced walk-away time and high throughput for fully automated processing of permeability assays, while automated miniaturised shake-flask solubility assays can be done with the similarly configured Usol Evolution.
The flexibility of the Freedom Evo workstation also allows the same instrument to perform both permeability and solubility assays in a combined set-up, as well as other ADME assays.
The advanced Quad4 Monochromators technology in the Infinite M200 provides high sensitivity and an optional Multichannel Arm 96 in the Freedom Evo platform increases throughput with rapid sample transfers.
