The Morphologi G3 automated particle characterisation system from Malvern Instruments is being used to examine pollen in support of allergy research.
The Morphologi G3 is capable of analysing thousands of pollen particles in minutes, with little or no user intervention, the company said.
Compared with the manual microscopy techniques traditionally used for pollen purification and characterisation, the Morphologi G3 delivers savings in both time and manpower.
The clinical efficacy of allergy diagnostic and immunotherapy products is highly dependent on the composition of the active allergen used as source material.
Effective characterisation of source material during the manufacturing process is therefore essential.
Analysing pollen samples with the Morphologi G3 allows the automated characterisation of pollen in terms of size and shape.
Results enable differentiation between multiple pollen types and, together with the particle images, allow the user to ensure that only the desired pollens are present in a sample.
Mixed pollen samples can be further characterised to determine constituent proportions.
At the push of a button, the Morphologi G3 analyses hundreds of thousands of particles, delivering: particle shape, particle count and size information; statistically significant data; high-resolution images of every particle; full automation; compliance with 21CFR Part 11; and integrated sample dispersion.
Pollen samples were dispersed using the integrated sample dispersion unit, via an instantaneous pulse of compressed air.
Standard operating procedures defined the instrument's software and hardware settings.
Different types of pollen can be automatically classified based on their size and shape.
