Capsugel has launched the automated CFS 1500 C (containment) capsule filling and sealing system.
The CFS 1500 C is said to provide rapid and safe filling and sealing of capsules containing lipid-based formulations or potent compounds for use in early phase clinical trials.
The system, which utilises Capsugel's Licaps Drug Discovery System technology, has been developed to enable easy movement and integration into suitable containment equipment.
In addition, the CFS 1500 C system has been designed to facilitate ease of cleaning and also to ensure that compounds remain within the working area.
It has readily accessible moving parts that can be removed for manual or auto washer cleaning.
This combination of features aims to help ensure scientists can safely work with lipid-based formulations or potent compounds and be confident that they will not contaminate their equipment or different capsule batches.
The CFS 1500 C system has an increased throughput of 1,500 filled and sealed capsules per hour and is scalable to commercial manufacturing using the Liquid Encapsulation Micro-spray Sealing (LEMS) system, which is capable of sealing up to 70,000 capsules per hour.
Using the LEMS 70 system's micro-spraying technology in conjunction with Capsugel's Licaps capsules, the CFS 1500 C system can fill and seal capsules with a robust, impervious seal.
One of the key factors in getting the best seal for a liquid-filled capsule is a clean precise dosing system; to enable this, the CFS 1500C system features Capsugel's liquid dosing technology, which is said to allow precision dosing and prevent the occurrence of drips.
In addition, the new software design provides greater functionality and, in combination with a new weigh-cell feature, measures the weight of each filled capsule to ensure compliance with 21 CFR part 11 requirements.
