Taylor Technology has announced that it is offering complete pharmacokinetic (PK) studies, including dosing, sample shipment, analysis, and data reporting in five days or less.
This offering is part of the CRO's strategic alliance with Aniclin Preclinical Services.
Taylor will leverage Aniclin's complementary services and technology to enhance bio-analytical programme support and in vivo services.
Traditionally, PK studies can take weeks to complete.
By combining Aniclin's services, Taylor Technology offers Fast PK package (IV and PO) that includes formulation, dosing, PK sampling, transfer of samples to the lab and bio-analysis (plasma) of six time points, inclusive of quality control samples and front-and-back standard curves - all in five days or less.
The accelerated timeline involves the new chemical entities arriving at Aniclin, where dosing is performed.
The collected plasma samples are then delivered to Taylor Technology within two hours.
Upon receipt, the plasma samples are immediately processed for LC-MS/MS using a Hamilton Microlab Starlet robotics platform.
In addition to providing PK estimates, Taylor Technology employs the Thermo Scientific Exactive LC-MS system for semi-quantitative metabolite analysis data during the Fast PK assay.
Taylor Technology believes such an approach adds value in support of Fail Fast paradigm of drug discovery, which is critical to improving success rates in early discovery through lead optimisation.
By utilising the Thermo Scientific Orbitrap technology, the company is able to offer customers early metabolism data using accurate mass and mass defect filtering (MDF), without much added cost.
