Malvern Instruments has established a gateway within its website to provide information on orally inhaled and nasal drug products for therapeutics applications.
The gateway guides visitors directly to technical information, downloadable application notes, case studies and interactive presentations on particle-size measurement for this class of product.
Upon entering, visitors can choose to go directly to information on particle sizing in nasal sprays, inhalers or nebulisers.
Malvern's Spraytec system is widely used in particle analysis, from early development through to manufacturing and quality control.
The advanced laser diffraction particle-size analyser is designed specifically for spray droplet and dry-powder aerosol measurements.
A robust system with SOP-driven operation, it offers: rapid data acquisition for real-time monitoring of particle-size changes during a spray event; a dynamic range from 0.1 to 2,000um, covering the sub-10um range of primary interest for pulmonary delivery, nasal sprays and the characterisation of poorly dispersed agglomerates; and concentration measurement, which, in combination with size data, enables the dynamic study of dispersion behaviour.
A powerful tool for rapid screening and accelerated optimisation of OINDPs, Spraytec complements techniques such as cascade impaction, adding detailed insight into dispersion and atomisation behaviour.
Such information promotes an efficient, knowledge-led approach to device and formulation development, as advocated by QbD.
