Midsci is offering the TPP Bioreactor Tube, which is suitable for the high-throughput screening of cells and media optimisation for suspension cell systems.
The TPP solution meets the needs of biopharmaceutical companies that want to increase the yields of recombinant proteins at a fast and economical rate.
Media optimisation is said to be an expensive process owing to the cost of supplies and increased man hours during repeat experiments.
The TPP Bioreactor Tube has been designed to allow parallel experiments, thus eliminating repeats.
The instrument resembles a standard 50ml conical tube (a 600ml bottle will be available soon) with a cap that allows the optimal gas exchange of carbon dioxide, oxygen and humidity.
The cap contains five holes of different size and a 0.22um PTFE membrane filter.
Researchers have the opportunity to regulate gas exchange rates by concealing varying combinations of the cap holes.
Determining optimal gas exchange rates during media optimisation is where research laboratories waste time and money.
Money savings with the TPP Bioreactor Tube come with the time saved from growing cells in parallel in multiple tubes with varying exchange rates, according to Midsci.
The gas porous filter of the TPP Bioreactor Tube guarantees oxygen supply even at high tissue densities.
The hydrophobic membrane maintains sterility and minimises the evaporation of media.
All tubes are manufactured to be certified nuclease, nucleic acid and pyrogen free.
All of these features have been quality assured by TPP quality-control measures.
The protocol is said to be simple and is complete after the fine tuning of process conditions.
The company claims that researchers can expect maximum cell growth and recombinant protein yields.
As multiple mammalian cell lines are used for recombinant protein growth, the quick optimisation of future cell lines is simplified.
The TPP Bioreactor Tube cuts costs by ensuring efficient gas exchange and minimal media consumption (10-30ml per tube) and by enabling quick, parallel experiments to be performed.
Being completely disposable, it fills the gap between multi-wall plates for the initial screening of clones and instrumented laboratory-scale bioreactors for the fine tuning of process conditions, according to Midsci.
