Malvern Instruments has released an application note explaining how the low-angle light scattering (LALS) technique can measure a scattered light intensity directly proportional to molecular weight.
The application note, entitled 'LALS or why closer is better', discusses the use of the LALS technique when measuring samples utilising gel permeation chromatography/size exclusion chromatography (GPC/SEC).
By avoiding the issues caused by data extrapolation or data fitting, which limit the alternative techniques of multi-angle light scattering (MALS) and right-angle light scattering (RALS)/viscometry, Malvern's Viscotek LALS detector allows GPC/SEC practitioners to accurately measure the molecular weight of their samples.
In addition, the small size and simplicity of the LALS detector allows it to be used in integrated multi-detector systems alongside viscometers, enabling the simultaneous determination of both molecular weight and molecular structure.
Visit the company's website for more information on the Viscotek LALS detector, the TDAmax GPC/SEC and other chromatography systems and to download the application note.
