Agilent Technologies has released the Sureselect XT Target Enrichment System for next-generation sequencing.
Sureselect XT combines sequencing library preparation and gDNA preparative reagents with the proven Sureselect target-enrichment system.
Target enrichment streamlines workflows by letting researchers sequence just the genomic regions of interest, rather than entire genomes.
The multiplexing support capabilities of the Sureselect XT platform make it possible for geneticists to interrogate the genome of more samples per study than previously possible.
One of the rate-limiting steps in such studies has been library preparation and target enrichment.
To enable high-throughput sample processing efficiency, Agilent has now released an integrated workstation that automates Sureselect XT library preparation and target-enrichment workflows.
This system results in greater throughput, up to 192 samples weekly per workstation, and enables greater lab productivity for fast and robust data generation.
Agilent also expanded its target-enrichment intellectual property when it received notice of allowance of US patent application number 10/927,809 for element-defined sequence complexity reduction.
The patent comprises a method for providing defined mixtures of nucleic acids.
In certain embodiments, the method uses oligonucleotide probes attached to a solid support as a sequence-specific affinity agent to isolate and facilitate the amplification of defined nucleic acid fragment mixtures.