Malvern is to showcase the benefits of integrating the automated size/shape analysis of particles with the chemical identification provided by Raman spectroscopy, using its Morphologi G3-ID system.
For pharmaceutical scientists, the company will highlight the Viscotek TDAmax, a gel permeation/size exclusion chromatography (GPC/SEC) system, which is one of a range of Malvern's polymer/protein characterisation solutions.
Applications for the Morphologi G3-ID include the characterisation of inhaled formulations, where it complements Malvern's Spraytec system.
With nasal sprays, for example, deposition relates to the delivered droplet size while bioavailability depends on factors that include the size distribution of the API.
Laser diffraction analysis using Malvern's Spraytec system enables the monitoring of changes in droplet size while analysis with the Morphologi G3-ID permits the detection of even subtle changes in API size distribution.
Similarly with dry-powder inhalers, techniques that can follow the process of particle dispersion, and then identify which species have been dispersed to a respirable particle size, can offer benefits, especially when developing new combination therapies.
When it comes to protein and polymer characterisation, Malvern's Viscotek TDAmax GPC/SEC system measures absolute molecular weight without correction or extrapolation, molecular size (Rh to less than 1nm and Rg), and intrinsic viscosity.
Its triple detector array features a low-angle light-scattering detector, four-capillary differential viscometer, and differential refractive index detector.
An optional UV or PDA (photodiode array) detector can be added to give compositional information.
