A new article demonstrates the effectiveness of combining laser diffraction and automated particle imaging (including Raman spectroscopy) in the characterisation of nasal spray products.
Co-authored by materials characterisation specialists from Malvern Instruments, together with Julie Suman, president of Nextbreath, 'Characterising a nasal spray formulation from droplet to API particle size' can be downloaded from Malvern's website.
The authors used both the Spraytec laser-diffraction droplet-size analyser and the Morphologi G3-ID automated particle-imaging system with Raman spectroscopy to characterise a nasal spray product.
First they describe the analysis of spray formation dynamics, droplet size and effective dosage at different spray velocities and the results achieved using the Spraytec.
They then distinguish between active pharmaceutical ingredient (API) and insoluble excipients in a suspension, as well as API particle size distribution before and after dispersion, using the Morphologi G3-ID.
Specifically designed to address the requirements of aerosol and spray droplet characterisation, Spraytec provides in-situ, real-time droplet-size measurements.
The Morphologi G3-ID integrates automated image analysis with Raman chemical identification to detect subtle changes in particle composition and structure.
Together they enable rapid formulation optimisation for oral and inhaled nasal drug products.
